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Promethazine HCl Oral Solution ought to be employed with caution in clients with bone-marrow melancholy. Leukopenia and agranulocytosis are already noted, generally when Promethazine (Promethazine HCl) continues to be Utilized in association with other recognised marrow-poisonous agents.Promethazine HCl Oral Solution is contraindicated in comatose